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How alcohol disrupts methylation nutrients Impairs intestinal absorption of folate, B6, and B12 Interferes with hepatic storage and activation of methylation cofactors Increases demand for SAMe during detoxification and oxidative stress Common symptoms and clinical consequences of Poor methylation Fatigue and low stress tolerance Mood changes, anxiety, or depression Brain fog and memory difficulties Anemia or elevated homocysteine Increased cardiovascular and cancer risk with long-term deficiency (37) Clinically, methylation-related deficiencies often show up as a combination of low energy, mood instability, and poor detox tolerance—patients feel overwhelmed by stressors they previously handled without difficulty

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J Med Genet