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This has been the case with GHI, which is now known not to be a single entity, but a broad diagnostic category comprising a range of defects affecting the function of the IGF system

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The main strategies include osmotic disruption through intracarotid infusions of mannitol, modification of tight junctions by the administration of bradykinin analogues, and focused ultrasound techniques ( Carrier Molecules to Overcome the Blood-Brain Barrier: Nanoparticle Formulations Nanoparticles have been explored to protect drug entities in the systemic circulation and facilitate the uniform delivery of drugs across previously impenetrable barriers ( Chemotherapy-Induced Neurotoxicity: A Lack of Specificity Traditional and modern chemotherapy and radiotherapy can have undesirable effects on the CNS, which can result in the discontinuation of the treatment or dose-adjustments that prevent the achievement of a desirable therapeutic outcome [reviewed by ( Radiation necrosis is a delayed complication of radiation therapy for brain tumors and a dose-limiting factor for stereotactic radiotherapy, a standard treatment for brain metastases ( Acute and chronic complications of the CNS following chemotherapy treatment are common