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After first puncture, the 28-day USP rule applies — the bacteriostatic activity of the benzyl alcohol declines slowly over time as the preservative metabolises, and after 28 days the vial should be considered for disposal regardless of remaining volume

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To mitigate DEHP’s impact on breast health, individuals should minimize environmental exposure, choose DEHP-free products—especially during pregnancy and lactation—and follow regular breast health exams and early screening protocols