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In primary liver cancer models in vivo and TGF-β1-induced human HCC (HepG2) cells in vitro, AS-IV can promote Nrf2/HO-1/NQO1 signaling transduction and upregulate the antioxidant activity of pNrf2 and its downstream proteins to alleviate the progression of liver fibrosis and primary liver cancer (167,180)
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doi: 10.3389/fimmu.2021.688643 [DOI] [PMC free article] [PubMed] [Google Scholar] 173.Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y, Vergely C
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