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Moreover, species and sex differences in the mechanisms by which certain haloalkene cysteine S -conjugates are bioactivated must also be considered when evaluating the nephrotoxicity of halogenated cysteine S -conjugates (e.g., Birner et al., 1995, Lash et al., 1998, Lash et al., 2014)

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Aberrant Crypt Foci (ACF) Analyzing the number of aberrant crypt foci observed in groups V, VI, VII and VIII, by colonic segment (proximal, middle or distal), as well as its entire extension, statistically significant differences were observed between the groups (P = 0.0495) in the distal colon (Figure 16), comparisons between groups in pairs, using Dunn’s multiple comparison test, showed only a marginally significant difference (P = 0.0513) between groups VIII (DMH-GA-EUG) and VII (DMH-EUG)