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Unlike plant GDHs, mammalian mitochondrial GDHs use both NAD + and NADP + , allowing mitochondria to use glutamate as an NADH source for the mETC when required (Bunik et al., 2016
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SAM-e is required for cellular growth and repair and is the sole methyl donor for numerous methyl-transfer reactions in DNA, RNA, proteins, lipids, phospholipids, hormones and neurotransmitters
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