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The C-terminal helices 13 and 14 of one hexamer was interlocked with the C-terminal helices of the opposite hexamer via hydrophobic interactions (A461, F464, P465, W466, P472, F473, F475, and I476) and hydrogen bonds (E462 Oε1 to T478 Oγ1, K469 O to H471 Nε2, P470 O to H471 Nε2, H471 Nε2 to K469 O, H471 Nε2 to P470 O, E474 Oε1 to T326 Oγ1, E474 Oε1 to K330 Nζ, E474 Oε2 to N327 Nδ2, T477 O to K35 Nζ, T478 Oγ1 to E462 Oε2, Y479 OH to T262 Oγ1, Y479 OH to A263 N, S480 O to L253 Nζ, and C481 Sγ to S373 O) (Fig
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In conclusion, ferroptosis is strongly correlated with tumor cell growth and invasion, as well as drug resistance
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