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In a murine ischemia–reperfusion AKI model, bardoxolone methyl significantly improved renal function and histopathological injury, while increasing renal expression of Nrf2, PPARγ, and HO-1, indicating that enhancement of endogenous antioxidant defense contributes to its renoprotective effect (256)
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However, glutamate at high concentrations at the synaptic cleft acts as a toxin, inducing neuronal injury and death (Meldrum, 2000
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