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Research indicates that TGF-β1 modulates renal injury by stimulating downstream Smads, where Smad3 is a key mediator that promotes renal fibrosis, Smad2, and Smad7 have renal protective effects, and Smad4 exhibits both promotion of fibrosis and inhibition of inflammation through different mechanisms (191)

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Tesamorelin is a GHRH analog with FDA approval for HIV‑associated lipodystrophy and a substantial research record on visceral adipose reduction