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These metabolite changes suggest that the retrograde signal may involve altered activity of chromatin-modifying enzymes sensitive to these metabolites
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Consequently, there has been a drastic increase in the use of 3T3-L1 adipocytes as a model to screen pharmacological and natural compounds [[9], [10], [11], [12]], including those dissolved in DMSO for their therapeutic potential against obesity and its associated complications [13]
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