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Concurrently, hyperinsulinemia synergizes with LH to stimulate ovarian theca cells, enhancing cytochrome P450 family 17 subfamily A member 1 (human gene CYP17A1) and 3β-hydroxysteroid dehydrogenase (3β-HSD) activity to boost androstenedione and testosterone synthesis (47)
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Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes
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