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Heat stress causes denaturation of protein and membrane lipids, enzyme inactivation, inhibited protein synthesis, and loss of membrane integrity [144], which results from the disruption of cellular homeostasis through the ROS formed in a mass amount under heat stress [143,145]
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Unlike other drug trials, integrative oncology studies encounter additional methodological issues such as the plethora of supplement formulations and their composition, variability in concentration of bioactive compounds across different source materials, patient-driven simultaneous use of products and multifaceted endpoints that include tumour response objective assessments as well as symptom control, quality-of-life evaluation, and biomarker modification (19)
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