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Peripheral neuropathy (PN) In PN, nerves in the arms and legs are damaged, leading to a variety of symptoms, including pain, burning, numbness, tingling, loss of balance and co-ordination, and muscle weakness

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TRPV1 was later discovered in several areas of the central nervous system, including dopaminergic neurons in the substantia nigra, the hippocampus, hypothalamus, cortex, cerebellum, dentate gyrus, and nucleus accumbens