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These studies demonstrate a novel pathway through which the status of GSH can enhance the levels of 25(OH)VD and that the use of combined VD+LC supplementation significantly lowers inflammation and increases the levels of GSH, vitamin D regulatory genes, and VDR, all of which are required to raise the blood levels of 25(OH)VD and reduce the inflammation levels
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This process is coordinated in early development by the long non-coding RNA (lncRNA) XIST, which is first transcribed and afterwards it spreads in cis across the inactive X-chromosome
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