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Frontiers | Current and emerging therapeutic strategies for amyotrophic lateral sclerosis: from pharmacological approaches to gene and stem cell therapies
Finally, DAO deficiency can be a temporary and reversible condition, caused by the inhibitory effect of substances such as biogenic amines and alcohol, as discussed above, as well as several widely used drugs (Table 2) [1,10]
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These mutations lead to inadequate levels of the enzyme, very long-chain acyl-coenzyme A dehydrogenase resulting in the accumulation of long-chain fatty acids and patients are unable to make ketone bodies for energy
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