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Glutathione S-transferase Theta 2 causes drug resistance by inhibiting arsenic trioxide-induced ferroptosis in pancreatic ductal adenocarcinoma - ScienceDirect

This observation is consistent with studies of Arabidopsis apx1 knockouts (Davletova et al., 2005), and suggests that the cytosolic ascorbate-glutathione pathway is important in metabolizing H 2 O 2 originating in other compartments

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ISD11 deletion (Figure S6H) mimics NFS1 deficiency, increasing Fe 2+ (Figure S6I), lowering OCR (Figure 5H, S6J), and proliferation (Figure 5I)