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Whole-genome bisulfite sequencing was then applied to assess DNA methylation in the NAc
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A periodic simulation box was developed using the system builder module, the system was solvated using the TIP3P (Transferable Intermolecular Potential with 3 Points) water model and neutralised by adding counter ions, and energy minimization was achieved using the OPLS with 1000 iterations of the steepest descent technique (Optimized Potentials for Liquid Simulations) all atoms force field
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