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You will learn: • Why pediatric patients are more susceptible to cold injuries • How to determine the severity of hypothermia, based on the patient’s core body temperature and associated clinical findings • What types of thermometers are appropriate for use in patients with hypothermia, as well as temperature measurement strategies • When CPR should be initiated, and when it is appropriate to stop resuscitation efforts • When diagnostic studies are warranted, and which studies should be ordered for patients at different stages of hypothermia • Types of rewarming techniques, including passive and active rewarming methods • How to manage patients with mild, moderate, or severe hypothermia, as well as those with frostnip or frostbite • Indications and evidence for the use of extracorporeal membrane oxygenation Abstract Case Presentations Introduction Critical Appraisal of the Literature Etiology and Pathophysiology Hypothermia Peripheral Cold Injuries Frostnip Frostbite Differential Diagnosis Prehospital Care Emergency Department Evaluation History Physical Examination Vital Signs Other Physical Examination Findings Peripheral Cold Injuries Diagnostic Studies Laboratory Studies Other Studies Treatment Hypothermia Mild Hypothermia (Hypothermia Stage I) Moderate Hypothermia (Hypothermia Stages II and III) Hypothermia Stage II Hypothermia Stage III Severe Hypothermia (Hypothermia Stage IV) Airway Management Circulatory Support Irrigation for Rewarming Extracorporeal Membrane Oxygenation Peripheral Cold Injuries Special Circumstances Afterdrop Hypothermia in the Wilderness Setting Hypothermia After Trauma Therapeutic Hypothermia in Children Controversies and Cutting Edge Disposition Summary Risk Management Pitfalls in Management of Pediatric Patients With Cold Injuries Time- and Cost-Effective Strategies Case Conclusions Clinical Pathway for the Management of a Pediatric Patient With Hypothermia Tables and Figures Table 1
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Studies show that glutathione conjugates bind to lipophilic xenobiotics and facilitate their excretion through specialized efflux transporters
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