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Gastrointestinal side effects were mostly mild to moderate, with the highest incidence in the 8 mg fast escalation group [114]
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Indeed, recent studies have leveraged techniques like mass spectrometry and nuclear magnetic resonance (NMR) to quantitatively measure metabolites in murine pancreatic and lung tumors, and to accurately measure the flux of lactate between tumor cells and the interstitium [127,128]
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