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Chronologically at age 60 the frequency of AD is approximately 1%, at 65 years 10 %, at 85 years 30% and is now the sixth leading cause of death in the U.S
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To bridge the adult behavioral data to the in vitro mechanistic theory, organotypic hippocampal slice cultures that maintain an environment representative of an intact hippocampus were employed and evaluated for treatment-induced spinogenesis
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