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Moreover, TNF-α induces the production of ROS, further activating the transcription factor, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which in turn induces the production of proinflammatory cytokines such as TNF-α [52]

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++ Exclude ACOs that fall below 5,000 assigned beneficiaries in any benchmark year from being eligible to leverage existing policies that provide certain low revenue ACOs participating in the BASIC track with increased opportunities to share in savings (section III.F.4.c.(2)