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Chen F., Tang C., Yang F., et al., “HSP90 inhibition Suppresses Tumor Glycolytic Flux to Potentiate the Therapeutic Efficacy of Radiotherapy for Head and Neck Cancer,” Science Advances 10, no
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Its nuclear translocation can be inhibited by the antimalarial drug artesunate (ART), which leads to decreased transcriptional levels of HMGCR and reduced levels of IPP, thus impeding the synthesis of GPX4 and resulting in ferroptosis [146]
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