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Nootropic ingredients to limit or avoid Not many common nootropic ingredients are inherently dangerous, but a few pose higher risks than most: Vinpocetine can induce miscarriages or birth defects if taken while pregnant77 Huperzine A can cause acetylcholine toxicity if taken in high doses for too long70 Ashwagandha may contribute to thyroid complications, as highlighted in case studies.100 34 ( Note: Although some anecdotal reports suggest it may induce miscarriage, as well, the American Herbal Pharmacopoeia has found no pharmacological mechanism by which it could do so.)78 118 There’s also the matter of ingredients that are essentially fillers, having little to no research support behind their supposed nootropic effects