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Activating Vitamin B12 in Humans
CRISPR systems using the Cas9 endonuclease or the catalytically inactive Cas9 (dead Cas9 or dCas9) with single-guide RNA (sgRNA) libraries targeting every protein-coding gene in the human genome have been used as discovery tools for many biological questions, including regulation of GPCR trafficking 29 , phagocytosis 30 , and neutrophil migration and differentiation 31
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The body mass of subject(s) will also impact appropriate dosing
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