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Mutations in genes encoding enzymes of the UPS result in renal disease, and mutations in kidney-specific genes result in ubiquitin–proteasome dysfunction that leads to renal disease

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Part of what's so fascinating about this drug is that it's getting rid of the fungus and mold, it's improving gut integrity— I've had multiple families where their kids have had 2 or 3 years of chronic constipation or diarrhea, and then literally 3 or 4 weeks later, "Oh my God, this is the first normal poop she's had her entire life." So it improves the gut, it improves the microbiome, it gets rid of the fungus, and simultaneously it's actually influencing multiple cascades of immunity within the systemic and nervous system all at the same time, which to me is so fascinating to reflect on