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These functional biomechanical defects lead to excessive, repetitive overload of the Achilles tendon, which further aggravates tendinopathy
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Vorasidenib was approved by the FDA in 2024 for the treatment of adults and adolescents aged ≥12 years with World Health Organization (WHO) grade 2 astrocytoma or oligodendroglioma harboring an IDH mutation, based on the phase III INDIGO trial, which demonstrated an improvement in median PFS from 11.1 to 27.7 months versus placebo [269,270]
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