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Frontiers | Programmed cell death in Helicobacter pylori infection and related gastric cancer

In another experiment, infusions of the cholinotoxin 192 IgG-saporin on 12 male BNNia/F344 four-month old rats induced loss of cortical cholinergic inputs, which in turn resulted in the rats’ impaired performance in a sustained attention test, while performance on non-attention related control activities was unaffected (47)

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Disclosure of interest: Yes INTRACEREBRAL HAEMORRHAGE 1391 COMORBIDITY IN ORAL ANTICOAGULANT-RELATED INTRACEREBRAL HEMORRHAGE Josefine Liv Gilling Grundtvig* 1,2 , Christian Ovesen 1 , David Gaist 3 , Thorsten Steiner 4,5 , Hanne Christensen 1,2 1 Bispebjerg and Frederiksberg Hospital, Department of Neurology, Copenhagen, Denmark , 2 University of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark , 3 Odense University Hospital and University of Southern Denmark, Research Unit for Neurology, Odense, Denmark , 4 Klinikum Frankfurt Höchst, Department of Neurology, Frankfurt, Germany , 5 Heidelberg University Hospital, Department of Neurology, Heidelberg, Germany Background and aims: We aimed to explore if background morbidity was comparable in participants from large direct oral anticoagulant (DOAC) trials and patients admitted with oral anticoagulant-related intracerebral hemorrhage (OAC-ICH)