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J Exp Med (2020) 217(10):e20200389

Wound Healing

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Combined with previous evidence demonstrating that dorsal spinal cord lamina I neurons receiving input from unmyelinated C fibers increase their firing frequency during skin warming in cats (127), and that dorsal horn neurons project to the LPB (128), the study by Nakamura and Morrison (125) established the existence of an afferent pathway from primary somatosensory neurons in the skin that, when activated by innocuous warmth, relay afferent information to secondary order neurons in the dorsal horn of the spinal cord which, in turn, project to third-order neurons located within the LPBd that project to quaternary neurons within the MnPO nucleus of the POA (FIGURE 4)