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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

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L-cysteine supplementation also helps to prevent the downregulation of vitamin D regulatory genes by way of increasing GSH N-Acetylcysteine (NAC) is another form of cysteine that is considered “…less toxic, less susceptible to oxidation (and dimerization) and is more soluble in water, making it a better source of cysteine than parenteral administration of cysteine itself.” GSH is necessary to help protect our cells from damage due to oxidative stress, mercury and other toxic metals, alcohol, persistent organic pollutants, and much more