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β-oxidation occurs in the mitochondrial matrix and involves a repetitive sequence of four reactions: oxidation, hydration, a second oxidation, and cleavage (thiolysis), each removing a two-carbon unit from the fatty acid chain [81]
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DNA methylation is initiated and established by means of the de novo DNA methyltransferase DNMT3 family (DNMT3A and DNMT3B) [11, 19] (Fig
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