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To discriminate between these two possibilities, we first diminished the reduction of thiols by knocking down GSR ( gsr-1 ) or glucose-6-phosphate dehydrogenase ( gspd-1 ), the enzyme which generates NADPH, the cofactor required by all GSSG-reducing enzymes (Fig

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Since there is high-level evidence to suggest that in the appropriate patient, varicocelectomy results in improvement of outcomes,34 treating infertile men with a varicocele with drugs alone cannot be recommended