foxo4 dri peptide senolytic 2023 2024 study as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting Aminos

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The fragment retains the motif responsible for the interaction with monomeric G-actin, but does not reproduce the full repertoire of biological activity of the entire protein – full Tβ4 carries additional domains involved in angiogenesis, modulation of inflammation and reepithelialization, which the heptapeptide itself does not fully replicate