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Although the specific connection between NRLP1 and vitiligo is not completely defined, it is likely that inflammasomes, including NRLP1, play an important role in the inflammatory and cell stress processes that characterize this disease.13,14 Type 1 interferon pathway (IFN type 1) The IFN-1 pathway is an early and transient link in disease progression and marks the junction point between the innate and adaptive immune response
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X-ray crystallography indicates that functional P2X receptors are trimeric and three agonist molecules are required to bind to a single trimeric assembly in order to activate it [392, 441, 503, 581, 778]
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