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Consistent with this model, when NAD + was also added during the incubation period, and the lipoic arm was therefore in the reduced form for a shorter time, PDHC was also profoundly inhibited by RNS, but to a slightly lesser extent (Fig
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Since ROS are considered to play important roles in melanogenesis it stands to reason that, scavengers of ROS, such as antioxidants or antioxidant systems, may reduce hyperpigmentation or decrease melanogenesis
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