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Based on an SAR analysis, it was found that the anti-inflammatory potency of pyrazolo-isoquinolines may be related to the polarizability, location, and steric effects of substituents on the phenyl ring
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Alternatively, some GPx-1-deficient cells may be overwhelmed by oxidants because they lack other partially compensatory antioxidant mechanisms, resulting in heightened sensitivity to ROS and a lack of adequate pro-survival signaling
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