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Many small randomized trials and observational studies have shown increases in NK cell cytotoxicity, improvements in vaccine response, decreases in infection rates (via antiviral or stimulatory therapy), declines in chemotherapy-associated lymphopenia, and improved patient-reported outcomes (fatigue, QoL) with concomitant use of specific supplements (e.g., mushroom extracts/beta-glucans/ginseng)

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Compelling evidence also demonstrates that HIV-1 related proteins (e.g., HIV-1 envelope glycoprotein 120) and RNAs from infected cells act as potent pro-inflammatory stimuli, triggering neurotoxic microglial activation [14, 15]