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During ROS (H 2 O 2 ) detoxification, APX binds H 2 O 2 producing intermediate (I), and heme iron [Fe(V)] is oxidized forming oxyferryl species (Fe 4+ = O)
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showed that the blockage of CPT1A (with etomoxir) and the lipid synthesis/lipolysis (with orlistat) decreased the viability of the androgen-dependent prostate cell lines LNCaP, VCaP, and patient-derived prostate cancer cells 34
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