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Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ et al
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Moreover, they showed that, in comparison with melatonin alone, coadministration of a PDK-4 inhibitor with melatonin reduced EAE disability scores, inhibited pro-inflammatory and increased anti-inflammatory cytokines, decreased expression of oligodendrocytic markers in EAE, reduced lactate levels, increased N -acetyl aspartate (NAA) and 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase (HMGCR), and restored PDC function [45]
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