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RCSB PDB - 9UWM: A combined cryo_EM structure of Cagrilintide-CTR-Gs complex
The common trait among these different tissue-specific autoimmune disorders is likely the Th1-prevalent autoimmune response associated with elevated CXCL10 circulating level and reduced number of Tregs underlying a possible common pathogenic mechanism ( Genome-wide association studies (GWAS) underscored a clear genetic background shared between vitiligo and other autoimmune diseases (Spritz and Santorico, 2021)
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