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The length of telomeres shortens progressively with each cell division (mitosis) and is strongly associated with lifespan (Turner et al., 2019)
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Compound 3034, a small molecule inhibitor of Sb9, has recently been identified from an in vitro screening, which effectively restrains the growth of melanoma, breast cancer, kidney tumors, and lung cancer in vivo ( in vivo delivery of siRNA, especially tissue-specific delivery remains a challenge despite recent progress in siRNA delivery to liver
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