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A study demonstrated that ROS activation of the p62-KEAP1-Nrf2 signaling pathway has a tumor-suppressive effect [85]
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The basal activity of the HPA axis is regulated by a negative feedback which is mediated through activation of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), located in the pituitary and hypothalamus, by glucocorticoids [14, 15]
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