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This was sometimes mentioned in terms of receptor pharmacology, sometimes in terms of subjective effects (e.g., euphoria, feelings of warmth or contentedness, “nodding off,” analgesia), and sometimes in terms of cross-tolerance (e.g., mentions of tianeptine’s ability to attenuate opioid withdrawal symptoms, and mentions of tianeptine withdrawal symptoms that could be attenuated by buprenorphine, methadone, or kratom)

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