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Concentration dependence of Zn 2+ -induced changes in permeation While the site of action for high-affinity shift and slowing of Ca v 2.3 channel currents by Zn 2+ , Ni 2+ , and Cu 2+ is relatively well established, much less is known about the location of additional, lower-affinity sites for d-block metal ions, which appear to be present in most or all high-voltage activated (HVA) Ca 2+ channels (Neumaier et al., 2015)

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Urinary symptoms and incontinence in women: relationships between occurrence, age, and perceived impact

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