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Action Pharmacology: Carnitine orotate is nonhygroscopic (does not absorb/adsorb water from the surrounding environment), less deliquescent (does not readily liquefy when exposed to air) and is more soluble in water relative to the extremely hygroscopic L-carnitine

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4.2.1 Chemical drug-induced liver injury Glycyrrhizin activates the β-catenin signaling pathway, upregulates proliferation-related proteins (such as Proliferating Cell Nuclear Antigen (PCNA), Cyclin D1, and Cyclin-Dependent Kinase (CDK) 4), promotes hepatocyte proliferation and liver tissue regeneration, thereby effectively alleviating acetaminophen-induced acute liver injury and significantly reducing acetaminophen (APAP)-elevated serum ALT and AST levels (Xia et al., 2025)