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ACKNOWLEDGMENTS The work is supported by NIH grant HL089473, HL089473-02S1 to SVNP and AHA postdoctoral fellowship to NTV & MKG ABBREVIATIONS ADP adenosine-5’- diphosphate AKAP A-kinase anchoring protein AP-2 adaptor proein 2 ARNO ADP-ribosylation factor nucleotide binding site opener ATP adenosine-5’-trphosphate CCK cholecystokinin receptor CXCR chemokine receptor ERK extracellular-signal regulated kinase GDP guanosine-5’- diphosphate GIT GRK interacting protein GPCR G-protein coupled receptor GRK G-protein coupled receptor kinase GTP guanosine-5’- triphosphate I2PP2A inhibitor 2 of PP2A MAGI membrane-associated guanylate kinase inverted PDZ acronym combining the first letters of three proteins — P ost synaptic density protein (PSD95), D rosophila disc large tumor suppressor (Dlg1), and Z onula occludens-1 protein (zo-1) PI3K phosphoinositide 3-kinase PP2A protein phosphatase 2A PSD post synaptic density protein siRNA small interfering ribonucleic acid USP ubiquitin specific proteases Footnotes CONFLICT OF INTEREST Authors have no conflict of interests

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Niacinamide is a gentle, barrier-supporting all-rounder that calms redness and helps regulate oil