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Metformin affects macrophages' phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes ...

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The side effect profile reported in peer reviewed literature is mostly mild and short lived: soreness, transient swelling, temporary sensitivity and small bruises at injection sites, with serious complications rare when sterile technique is followed