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Inulin is a soluble, low viscosity fiber, and inulin-type fructans are supposed to have beneficial metabolic effects including bodyweight reduction and the normalization of blood sugar and cholesterol (166)

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It has been suggested that metformin displays potential beneficial effects by reducing several cardiovascular dysfunction risk factors, such as body mass index (BMI) (MD: −0.53 kg/m 2 , 95% CI −0.95, −0.12), insulin-resistance (HOMA-IR) (MD:−0.50, 95% CI −0.91, −0.09), triglyceride (MD: −0.11 mmol/L, 95% CI −0.20, −0.02), plasma plasminogen activator inhibitor-1 (Ruth, Day et al.) (MD: −4.99 ng/mL, 95% CI −6.78, −3.21) (Li and Li, 2023), carotid intima-media thickness (CIMT), and flow-mediated dilation (FMD) (Wang et al., 2024) in PCOS patients