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Inflammation and immune dysfunction in Parkinson disease | Nature Reviews Immunology

doi: 10.3892/etm.2022.11153 38 DengR.ChenX.ZhaoS.ZhangQ.ShiY

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2.1 Generation of ROS and reproductive vulnerability Oxidative stress arises in reproductive tissues through a convergence of mitochondrial dysfunction, inflammatory activation, and environmental insults, with profound implications for gamete viability and hormonal regulation ( Notably, the structural composition of reproductive cells renders them uniquely vulnerable to oxidative damage: sperm membranes are rich in polyunsaturated fatty acids (PUFAs), which undergo rapid lipid peroxidation