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In line with their findings on DNA methylation profiling, they observed that genes such as CD247, CD3E, CD3G, LCK, ZAP70, and CTLA4 have decreased levels of H3K4me3 and H3K27ac in their promoters regions in the CD8 + T cells of GD patients, which potentially may impede the function of T cell receptor signaling to inhibit CD8 + T cells (123) (Table 2)

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