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In mice, β3-AR receptors mediate cold-induced thermogenesis (223) and pharmacological activation of β3-ARs acutely stimulate lipolysis leading to two-fold increase in energy expenditure, a dramatic ten-fold increase in insulin levels, and 40–50% reduction in food intake (98)

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AMPK Inhibits Lipogenesis [58] When AMPK is activated, it first of all phosphorylates and then inhibits ACC1/ACC2, thereby leading to the reduction of malonyl-CoA which is a key substrate for fatty-acid synthesis